Studies
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Ongoing studies at VyNNL are focused on characterizing brain circuit abnormalities in psychosis, understanding how they relate to key symptoms, and determining whether these circuit abnormalities are specific to psychotic disorders.
Functional and Behavioral Dissection of Higher Order Thalamocortical Circuits in Schizophrenia
Functional and Behavioral Dissection of Higher Order Thalamocortical Circuits in Schizophrenia
In collaboration with our colleagues in the Thalamus Conte Center, this project will leverage discoveries in basic neuroscience to inform thalamocortical circuit dysfunction involvent in attention and executive functioning deficits in schizophrenia.
Principal Investigator: Neil Woodward
Research and Mentoring on Cognitive Neuroscience and High-Field MRI of the Thalamus in Schizophrenia
Research and Mentoring on Cognitive Neuroscience and High-Field MRI of the Thalamus in Schizophrenia
This project will apply methods from network science, cognitive neuroscience, and neuroimaging to characterize thalamocortical dysfunction in schizophrenia.
Principal Investigator: Neil Woodward
Negative Valence Systems in Schizophrenia
Negative Valence Systems in Schizophrenia
Comorbid anxiety disorders are common in schizophrenia and cause significant distress and impairment; yet little is known about the underlying causes. This study will determine whether individuals with schizophrenia have alterations in the ned nucleus of the stria terminalus (BNST), a region linked to anxiety in animal models, but is largely understudied in schizophrenia.
Principal Investigators: Brandee Feola, Neil Woodward
The General Factor of Psychopathology in Psychosis and Severe Mental Illness
The General Factor of Psychopathology in Psychosis and Severe Mental Illness
Growing evidence indicates the presence of a general factor of psychopathology that explains why many psychiatric disorders share similar symptoms. In this study, we will establish whether neuropsychological deficits and brain abnormalities observed in psychotic disorders relate to a general factor of psychopathology or a dimension of psychopathology specific to psychosis.
Principal Investigators: Stephan Heckers, Neil Woodward, David Zald
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