Research

We use neuroimaging and tools from cognitive neuroscience to characterize brain abnormalities in psychotic disorders and inform the mechanisms underlying the symptoms of psychosis. The goal of this work is to identify potential treatment targets for the symptoms and associated features of psychosis.

Representative Publication: A prefrontal thalamocortical readout for conflict-related executive dysfunction in schizophrenia. Cell Reports Medicine

Clinical symptoms, treatment response, and prognosis vary widely across individuals with neuropsychiatric disorders. Our research seeks to identify distinct subtypes and biomarkers to parse heterogeneity in psychotic disorders. Ultimately, we hope our work will inform the pathways leading to psychosis and contribute to more personalized interventions.

Representative Publication: Cerebellar structure and cognitive ability in psychosis. Biological Psychiatry  

Many psychiatric disorders emerge during adolescence and early adulthood, a crucial period of brain development. Our research on psychosis is grounded in a neurodevelopmental framework that emphasizes the importance of understanding brain development in both healthy individuals and at-risk groups to better identify and interpret brain abnormalities in clinical populations. 

Representative Publication: Lifespan development of thalamic nuclei and characterizing thalamic nuclei abnormalities in schizophrenia using normative modeling. Neuropsychopharmacology